Recent Publications
Sontag EM, Morales-Polanco F, Chen JH, McDermott G, Dolan PT, Gestaut D, Le Gros MA, Larabell C, Frydman J. Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear-vacuolar junctions and perinuclear ESCRT. Nat Cell Biol. 2023 May;25(5):699-713. doi: 10.1038/s41556-023-01128-6. Epub 2023 Apr 20. PMID: 37081164.
Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, Stachowiak J, Weber SC, White M, Zhang H, Zweckstetter M, Elbaum-Garfinkle S, Kriwacki R. Phase Separation in Biology and Disease; Current Perspectives and Open Questions. J Mol Biol. 2023 Mar 1;435(5):167971. doi: 10.1016/j.jmb.2023.167971. Epub 2023 Jan 21. PMID: 36690068; PMCID: PMC9970028.
Rolli S, Sontag EM. Spatial sequestration of misfolded proteins in neurodegenerative diseases. Biochem Soc Trans. 2022 Apr 29;50(2):759-771. doi: 10.1042/BST20210862. PMID: 35311889. Click here for the Accepted version of the manuscript.
Wu GH, Mitchell PG, Galaz-Montoya JG, Hecksel CW, Sontag EM, Gangadharan V, Marshman J, Mankus D, Bisher ME, Lytton-Jean AKR, Frydman J, Czymmek K, Chiu W. Multi-scale 3D Cryo-Correlative Microscopy for Vitrified Cells. Structure. 2020 Nov 3;28(11):1231-1237.e3. doi: 10.1016/j.str.2020.07.017. Epub 2020 Aug 18. PMID: 32814034; PMCID: PMC7642057.
Samant RS, Livingston CM, Sontag EM, Frydman J. Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control. Nature. 2018 Nov;563(7731):407-411. doi: 10.1038/s41586-018-0678-x. Epub 2018 Oct 31. PMID: 30429547; PMCID: PMC6707801.
Sontag EM, Samant RS, Frydman J. Mechanisms and Functions of Spatial Protein Quality Control. Annu Rev Biochem. 2017 Jun 20;86:97-122. doi: 10.1146/annurev-biochem-060815-014616. Epub 2017 May 10. PMID: 28489421.